252: Prolonged Tourniquet Conversion with Dr. John Holcomb

Last Updated: November 17, 2025

In this episode of the PFC Podcast, Dennis and Dr. John Holcomb discuss a study on ischemia reperfusion injury related to prolonged tourniquet use in combat settings. They explore the rationale behind the study, the criteria for patient inclusion, and the assessment of limb viability. The conversation delves into the implications of compartment syndrome, the management of reperfusion injury, and the importance of training medics in tourniquet conversion and replacement. The episode emphasizes the need for continuous learning from wartime experiences to improve combat medicine practices.

Takeaways:

The study focuses on ischemia-reperfusion injury after prolonged tourniquet use. A significant number of tourniquets applied in combat were unnecessary. Assessing limb viability involves the four C’s: color, consistency, contractility, and capillary refill. Compartment syndrome can occur even with effective tourniquet application. Reperfusion injury management is critical to prevent acute kidney injury. Dialysis needs vary based on tourniquet duration and injury severity. Training for tourniquet conversion and replacement is essential for medics. Seasonal variations may affect injury patterns on the battlefield. Continuous reassessment is vital in trauma care. Effective pressure dressings are crucial for managing bleeding post-tourniquet.