203: Freeze Dried Plasma with Doug

Last Updated: March 26, 2025

In this episode of the PFC Podcast, Dennis and ICU doctor Doug discuss the intricacies of resuscitation techniques, focusing on the use of freeze-dried plasma (FDP) and its benefits in trauma care. They explore the physiological aspects of trauma, the role of endotheliopathy, and practical applications of FDP in emergency situations. The conversation also touches on the comparison between FDP, whole blood, and albumin, highlighting the challenges and considerations in using these fluids for resuscitation. The episode concludes with a discussion on the future of blood products in trauma care and the importance of making FDP more accessible.

Takeaways:

FDP is a viable alternative to whole blood in trauma resuscitation.

Endotheliopathy of trauma can lead to widespread coagulation issues.

FDP helps stabilize the vascular endothelium during resuscitation.

Whole blood is preferred when available, especially in early resuscitation.

Albumin has limited benefits and can dilute clotting factors.

FDP has a longer shelf life and is easier to store than whole blood.

The physiological effects of trauma require careful consideration in resuscitation.

Resuscitation goals should focus on patient stability rather than strict numerical targets.

Acidosis can complicate trauma resuscitation and should be monitored closely.

Increased access to FDP could improve outcomes in trauma care.